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# FITOFÚNGICOS Tipos de prescripciones - Inferencia - "el criterio clínico" - Evidencia - científica - Profilaxis - 30-60 min antes de **CORTAR** la piel en **Q X** (Quirófano) ## ECHINOCANDINS * **MEDICATIONS** used to **TREAT** **MYCOSES** - **FUNGAL INFECTIONS** * **MYCOSES** can be **LOCALIZED SKIN INFECTIONS** - **SYSTEMIC INFECTIONS** in **IMMUNODEFICIENT PATIENTS** * **ANTIFUNGALS** - **FUNGISTATIC** - **INHIBIT FUNGAL GROWTH** - **FUNGICIDAL** - **KILL** the **FUNGI**  ## ECHINOCANDINS * **NON-COMPETITIVELY BIND** & **INHIBIT BETA-1,3-D-GLUCAN SYNTHASE** - **WEAKENS** the **CELL WALL** - **WALL RUPTURES** - **CELL DIES** * **ONLY AVAILABLE** via **IV** - **NOT WELL ABSORBED** through the **GI TRACT** * **ANIDULAFUNGIN MICAFUNGIN** & **CASPOFUNGIN** - **ONLY EFFECTIVE** vs. **SPECIES** with **BETA-1,3-D-GLUCAN SYNTHASE** - **RARE** for them to have **RESISTANCE** * **TREAT INFECTIONS** that are **RESISTANT** to more **COMMON** (fármacos) ## ECHINOCANDINS ## MUCOCUTANEOUS CANDIDIASIS * **SKIN**, **NAILS**, & **ORAL MUCOSA** DISSEMINATED CANDIDIASIS  © Copyright 2021-2022 Joyas ENARM - Todos los derechos reservados -  # POLIENOS ## POLYENES - **NATURALLY-DERIVED ANTIFUNGAL ANTIBIOTICS**  - **FUNGISTATIC** or **FUNGICIDAL** ## POLYENES AMPHOTERICIN B - INDICATIONS - **SYSTEMIC MYCOSES** - **ASPERGILLUS** - **BLASTOMYCES** - **CANDIDA ALBICANS** - **CRYPTOCOCCUS** - **HISTOPLASMA** - **MUCOR** - **VISCERAL LEISHMANIASIS** - **FEVER** - **WEIGHT LOSS** - **FATIGUE** - **ANEMIA** - **SWELLING** of **LIVER** & **SPLEEN** AMPHOTERICIN B - INDICATIONS SLOW **IV INFUSION** - poorly absorbed in **GI TRACT** - distributed in **ALL TISSUES EXCEPT CNS** **FUNGAL MENINGITIS INTRATHECAL ADMINISTRATION** - into **SPINAL CANAL** or **SUBARACHNOID SPACE**  AMPHOTERICIN B - SIDE EFFECTS - **INFUSION-RELATED** - **FEVER** - **CHILLS** - **MUSCLE SPASMS** - **VOMITING** - **HEADACHE** - **HYPOTENSION** - **ANAPHYLACTOID REACTIONS** - **RENAL TOXICITY**  - **ANEMIA** - decreased **GLOMERULAR FILTRATION RATE** - **IMPROVES** after **TREATMENT STOPS** - **RENAL TUBULAR ACIDOSIS** - **LOSS** of **Mg++** - **S.E.** - **HYPOKALEMIA** & **HYPOMAGNESEMIA** - **Mg++** - **S.E.** **SUPPLEMENTATION** - **ARRHYTHMIAS** - **IMPAIRED HEPATIC FUNCTION**   # TERBINAFINA  # GRISEOFULVINA ## GRISEOFULVIN  INDICATIONS - **DERMATOPHYTOSIS** of the **SKIN** & **NAILS**  **REPLACED** by **TERBINAFINE** & **AZOLES** ## SIDE EFFECTS  # FLUCITOSINA  - **CANDIDIASIS** - **CRYPTOCOCCAL MENINGITIS** - **CHROMOBLASTOMYCOSIS** caused by **MOLDS** - long-term **FUNGAL INFECTION** of **SKIN** & **SUBCUTANEOUS TISSUE**  # AZOLES ## AZOLE * **IMIDAZOLES**: **CLOTRIMAZOLE**, **ISOCONAZOLE**, **MICONAZOLE**, **BUTOCONAZOLE**, **FENTICONAZOLE**, & **KETOCONAZOLE** * **TRIAZOLES**: **FLUCONAZOLE**, **ITRACONAZOLE**, & **VORICONAZOLE**  * **INHIBIT 14-ALPHA-DEMETHYLASE** - **ALSO INHIBIT HUMAN CYTOCHROME P450** * **MAJORITY** come in **TOPICAL FORM** - **TREAT SUPERFICIAL MYCOSES**  * **DERMATOPHYTOSIS** or "**RINGWORM**" - **RED**, **ITCHY**, **SCALY**, **CIRCULAR RASH** - caused by **TRICHOPHYTON FUNGUS**  - "**ATHLETE'S FOOT**" or "**JOCK ITCH**" * **TINEA VERSICOLOR** - caused by **MALASSEZIA GLOBOSA** - **HYPOPIGMENTATION** or **HYPERPIGMENTATION** of **SKIN** * **YEAST INFECTIONS** - **ORAL** or **VAGINAL CANDIDIASIS** - caused by **CANDIDA SPECIES** * **COMMON SIDE EFFECT** is **SKIN IRRITATION**  * **HEPATOTOXIC** - **DAMAGE** the **LIVER** * **INHIBIT CYTOCHROME P450** - **BUILD-UP** of **MEDICATION** eg. **WARFARIN** & **PHENYTOIN** * **INHIBIT SYNTHESIS** of **ANDROGENS** - **GYNECOMASTIA** & **INFERTILITY** * **VORICONAZOLE** - **VISUAL DISTURBANCES** 
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# FITIF ÜNGICOS Tipos de prescripciones - Inferencia - "el crioque" - Evidencia - científica - Profilaxis \rightarrow 30-60 ~min antes de cortar la piel en Q x ## ECHINOCANDINS * MEDICATIONS used to TREAT MYCOSES - FUNGAL INFECTIONS * MYCOSES can be LOCALIZED SKIN INFECTIONS - SYSTEMIC INFECTIONS in IMMUNODEFICIENT PATIENTS * ANTIFUNGALS - FUNGISTATIC - INHIBIT FUNGAL GROWTH - FUNGICIDAL \sim KILL the FUNGI  ## ECHINOCANDINS * NON-COMPETITIVELY BIND \& INHIBIT BETA-1,3-D-GLUCAN SYNTHASE - WEAKENS the CELL WALL - WALL RUPTURES - CELL DIES * ONLY AVAILABLE via IV - NOT WELL ABSORBED through the GI TRACT * ANIDULAFUNGIN MICAFUNGIN \& CASPOFUNGIN - ONLY EFFECTIVE vs. SPECIES \omega / BETA-1,3-D-GLUCAN SYNTHASE - RARE for them to have RESISTANCE * TREAT INFECTIONS that are RESISTANT to more COMMON ## ECHINOCANDINS ## MUCOCUTANEOUS CANDIDIASIS * SKIN, NAILS, \& ORAL MUCOSA DISSERINATED CANDIDIASIS  © Copyright 2021-2022 Joyas ENARM - Todos los derechos reservados -  # POLIENOS ## POLYENES - NATURALLY-DERIVED ANTIFUNGAL ANTIBIOTICS  - FUNGISTATIC or FUNGICIDAL ## POLYENES AMPHOTERICIN B - INDICATIONS ## - SYSTEMIC MYCOSES - ASPERGILLUS - BLASTOMYCES - CANDIDA ALBICANS - CRYPTOCOCCUS - HISTOPLASMA - MUCOR - VISCERAL LEISHMANIASIS - FEVER - WEIGHT LOSS - FATIGUE - ANEMIA - SMELLING of LIVER \& SPLEEN AMPHOTERICIN B - INDICATIONS SLOW IV INFUSION - poriy aborbed in GI tract - subword in ALL TISSUES EXCEPT CMS FUNGAL MENINGITIS INTRATHECAL ADMINISTRATION - isis SPINAL CANAL or SUBARACHUOID SPACE  AMPHOTERICIN B - SIDE EFFECTS - INFUSION-RELATED - FEVER - CHILLS - MUSCLE SPASMS - VOMITING - HEADACHE - HYPOTENSION - ANAPHYLACTOID REACTIONS - RENAL TOXICITY  - ANEMIA - i GLOMERULAR FILTRATION RATE - IMPROVES after TREATMENT STOPS - RENAL TUBULAR ACIDOOS - LOSS of My- S.E. - HYPORALEMA \& HYPOMAGHESEMIA - My- S.E. SUPPLEMENTATION - ARRHYTHMIAS - IMPAIRED HEPATIC FUNCTION   # TERBINAFINA  # GRISEOFULVINA ## GRISEOFULVIN  INDICATIONS \sim DERMATOPHYTOSIS of the SKIN \& NAILS  REPLACED by TERBINAFINE \& AZOLES ## SIDE EFFECTS  # FLUCITOSINA  - CANDIDIASIS - CRYPTOCOCCAL MENINGITIS - CHROMOBLASTOMVCOSIS caused by MOLDS - long-term fungal infection of skin \& subcutaneous tissue  # AZOLES ## AZOLE * IMIDAZOLES: CLOTRIMAZOLE, ISOCONAZOLE, MICONAZOLE, BUTOCONAZOLE, FENTICONAZOLE, \& KETOCONAZOLE * TRIAZOLES: FLUCONAZOLE, ITRACONAZOLE, \& VORICONAZOLE  * INHIBIT 14-๔-DEMETHYLASE - ALSO INHIBIT HUMAN CYTOCHROME P450 * MAJORITY come in TOPICAL FORM - TREAT SUPERFICIAL MYCOSES  * DERMATOPHYSIS or "RINGWORM" - RED, ITCHY, SCALY, CIRCULAR RASH - caused by TRICHOPHYTON FUNGUS  - "ATHLETE'S FOOT" or "JOCK ITCH" * TINEA VERSICOLOR - caused by MALASSEZIA GLOBOSA - HYPOPIGMENTATION or HYPERPIGMENTATION of SKIN * YEAST INFECTIONS - ORAL or VAGINAL CANDIDIASIS - caused by CANDIDA SPECIES * COMMON SIDE EFFECT is SKIN IRRITATION  * HEPATOTOXIC \longrightarrow DAMAGE the LIVER * INHIBIT CYTOCHROME p450 - BUILD-UP of MEDICATION eg. warfarin \& phenytoin * INHIBIT SYNTHESIS of ANDROGENS - GYNECOMASTIA \& INFERTILITY * VORICONAZOLE \longrightarrow VISUAL DISTURBANCES 
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